Kratom & kava guides
Can You Convert 7-OH Milligrams to MIT? Why There Is No Reliable 1:1 Chart
Milligrams of 7-OH and milligrams of mitragynine (MIT) cannot be converted with a dependable ratio. The compounds differ in receptor activity, metabolism, concentration, and available human evidence; product form, other ingredients, individual physiology, tolerance, concurrent substances, and report accuracy add more variability.
Why a potency ratio is not a dose conversion
Mitragynine and 7-hydroxymitragynine both activate the mu-opioid receptor, but they do not activate it with the same potency. Receptor experiments measure a particular response in a particular test. They do not establish amounts that will produce equal effects, equal duration or equal risk in a person. See the human-receptor study.
The body changes mitragynine after it is taken
Researchers found that liver enzymes convert mitragynine into 7-OH in human and mouse liver preparations. Their mouse experiments also showed that this metabolite contributes to mitragynine’s pain-relieving activity. That is a metabolic pathway, not a fixed conversion rate for a person taking a commercial product. It does not mean swallowing mitragynine is equivalent to swallowing a calculated amount of 7-OH. See the metabolism study.
Can a lab report supply the missing ratio?
No. A COA can measure which compounds are in the tested product and how much is present. It cannot tell you how quickly your body will absorb or metabolize them, predict withdrawal relief, or establish an equivalent amount of another drug. Even an accurate potency result is not a substitution or tapering plan.
Reading the current MIT labels
“150mg MIT” is the Mango tablet label. Its tablet lab report lists 146mg mitragynine per tablet for lot M/150/002. “MIT 90%” is the extract-powder label; its source-material lab report lists 87.01% mitragynine for sample DD00126B(15). Neither number is a 7-OH equivalence or dosing instruction.
If the goal is to stop or replace 7-OH
A retail conversion chart is not a safe withdrawal plan. 7-OH can involve dependence and withdrawal. Contact a qualified clinician for individualized help; in the United States, Poison Control is available at 1-800-222-1222 for urgent exposure questions and SAMHSA's National Helpline is 1-800-662-HELP for treatment referrals.
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